ABSTRACT
Coombs' negative autoimmune hemolytic anemia (AIHA) is a rare disease which shares similar clinical and hematological features with Coombs' positive AIHA, but its exact frequency remains unknown. There have been few reports of idiopathic thrombocytopenic purpura (ITP) and Coombs' negative AIHA associated with other lymphoproliferative disorders (LPDs). Since there is a well known association between LPDs and autoimmune phenomena, it is important to investigate the possibility of an underlying malignancy. We report a case of ITP and Coombs' negative AIHA associated with diffuse large B-cell lymphoma.
Subject(s)
Humans , Anemia, Hemolytic , Anemia, Hemolytic, Autoimmune , Coombs Test , Lymphoma , Lymphoma, B-Cell , Lymphoma, Non-Hodgkin , Lymphoproliferative Disorders , Purpura, Thrombocytopenic, Idiopathic , Rare DiseasesABSTRACT
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) accompanied by a risk to develop colorectal dysplasia and cancer. Primary sclerosing cholangitis (PSC) is strongly associated with UC and there are some distinguishing clinical features between UC patients with PSC (UC-PSC) and UC patients without PSC. The most important feature is that UC patients with concomitant PSC are at a significantly increased risk of developing colorectal dysplasia or cancer. Furthermore, it has been suggested that patients with UC and PSC are also at an increased risk of cholangiocarcinoma. We report a case of cholangiocarcinoma and colorectal cancer diagnosed simultaneously in a patient with UC and concurrent PSC. He was diagnosed with UC and PSC 13 years ago and had been treated irregularly. Surveillance colonoscopy and biopsies were performed and one of the biopsied specimen confirmed adenocarcinoma. He underwent abdominal computed tomography (CT) because of the abnormal liver function test and the CT showed cholangiocarcinoma. To the best of our knowledge, this is the first case report of a UC-PSC with cholangiocarcinoma and colorectal cancer at the same time in Korea.
Subject(s)
Humans , Adenocarcinoma , Biopsy , Cholangiocarcinoma , Cholangitis, Sclerosing , Colitis, Ulcerative , Colonoscopy , Colorectal Neoplasms , Inflammatory Bowel Diseases , Korea , Liver Function Tests , UlcerABSTRACT
BACKGROUND/AIMS: Acute viral hepatitis A infection in adults is an emerging public health problem in Korea. The infectivity and pathogenicity of hepatitis A virus (HAV) among people living in close contact have not been studied previously. This study investigated the secondary attack rate and pathogenicity rate of HAV during an outbreak among auxiliary police in a communal living setting in Korea. METHODS: A total of 70 people in close contact with a hepatitis A patient (index case) were enrolled in the study, which included a thorough oral history, physical examination, and laboratory testing. The subjects were part of an auxiliary police unit living in a communal setting (HAV contact group). Serum antibody titers were measured in the contact group at two points during the study. Subjects in another auxiliary police unit without exposure to hepatitis A were examined as a control group (HAV non-contact group). The secondary attack rate and pathogenicity rate were calculated from the data. RESULTS: In the HAV non-contact group, none of the subjects had anti-HAV antibodies. In the HAV contact group, three subjects had both IgM and IgG anti-HAV antibodies, and two had only IgG anti-HAV antibodies. Two of three HAV-infected subjects were treated for hepatitis A. CONCLUSIONS: The secondary attack rate of HAV was 4.3~7.1% and the pathogenicity rate was 40~66.7% in the group of young adults.
Subject(s)
Adult , Humans , Young Adult , Antibodies , Hepatitis , Hepatitis A , Hepatitis A Antibodies , Hepatitis A virus , Immunoglobulin G , Immunoglobulin M , Korea , Physical Examination , Police , Public HealthABSTRACT
This report describes clinical and parasitological findings of an 82-yr-old female patient who lived in a local rural village and suffered from severe chronic anemia for several years. She was transferred to the National Police Hospital in Seoul for management of severe dyspnea and dizziness. At admission, she showed symptoms or signs of severe anemia. Gastroduodenoscopy observed hyperemic mucosa of the duodenum and discovered numerous moving roundworms on the mucosa. Endoscopy isolated seven of them, which were identified as Necator americanus by characteristic morphology of cutting plates in the buccal cavity. The patient was treated with albendazole and supportive measures for anemia, and her physical condition much improved. This case suggests the possibility that hookworm N. americanus is still transmitted in a remote local mountainous area in Korea.
Subject(s)
Aged, 80 and over , Animals , Female , Humans , Albendazole/therapeutic use , Anemia/diagnosis , Anthelmintics/therapeutic use , Duodenoscopy , Gastroscopy , Necator americanus/isolation & purification , Necatoriasis/diagnosis , Republic of KoreaABSTRACT
F-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET/CT) plays an important role in diagnosis of malignant tumors and adds to conventional imaging in the staging of pertoneal carcinomatosis. However, false positive cases resulting from benign disease such as tuberculosis may occur. We report two cases of peritoneal tuberculosis on F-18 FDG PET/CT which showed multiple hypermetabolic foci in the mesentery and peritoneum with increased serum cancer antigen 125 (CA 125). Subsequent F-18 FDG PET/CT showed a disappearance of pathologic uptake following treatment with anti-tuberculosis drugs.